Fertility & Sterility November 2004: A Polymorphism in the Resisten Gene Promoter Is Associated with Body Mass Index in Women with Polycystic Ovary Sydrome; Etiology of Azoospermia in 100 Consecutive Nonvasectomized Men
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Dacarbazine induces genotoxic and cytotoxic germ cell damage with concomitant decrease in testosterone and increase in lactate dehydrogenase concentration ... Toxicology and Environmental Mutagenesis]
This digital document is a journal article from Mut.Res.-Genetic Toxicology and Environmental Mutagenesis, published by Elsevier in 2006. The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser.
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Treatment of cancers with cytotoxic agents such as alkylating drugs often, but not always results in transient to permanent testicular dysfunction. The present study was planned to investigate the effects of dacarbazine [5-(3,3-dimethyltriazeno) imidazole-4-carboxamide] on testicular function in mice. Swiss albino mice (9-12 weeks old) were treated with 0, 5, 25, 50, or 100mg/kg body weight/day dacarbazine (i.p.) for 5 days at intervals of 24h between treatments. Mice were sacrificed on days 7, 14, 21, 28, 35, 49, and 70 after the last treatment (6 mice/dose/sample time), and the epididymal sperm count, sperm motility, sperm morphology, testicular histopathology (qualitativ
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Orignal From: Fertility & Sterility November 2004: A Polymorphism in the Resisten Gene Promoter Is Associated with Body Mass Index in Women with Polycystic Ovary Sydrome; Etiology of Azoospermia in 100 Consecutive Nonvasectomized Men
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